As this protein is secreted to the medium (Figure 4), the loss of function might be rather attributed to a different conformation or changes in the IL-23R binding mode compared to the AcmA-oriented, displayed REX variant interacting with the IL-23RCIgG chimera. REX protein binding variants were originally identified as binders of the human IL-23 receptor. … Continue reading As this protein is secreted to the medium (Figure 4), the loss of function might be rather attributed to a different conformation or changes in the IL-23R binding mode compared to the AcmA-oriented, displayed REX variant interacting with the IL-23RCIgG chimera